HGG Community Forums

This chart is old. I will post a link for the new one that has a good explanation. Basically, there are certain color patterns that, when bred together cause the foal to die before, or shortly after it is born

Oh, I hope I never come across that. Thank you.

This now only includes the Kit Lethality chart. Can we please include a link which reminds people about the splash and frame lethalities?

Is there a chart that includes the splash and fram lethalities? Or a thread that discusses them? I haven't seen them (not that I've been looking!)

If I understand the Splash and Frame lethalities correctly, they are:

Hom Splash 2 = lethal
Hom Splash 3 = lethal
Hom Frame = lethal
Het Splash 2 + Het Splash 3 = lethal
Het Splash 2 + Het Frame = ok
Het Splash 3 + Het Frame = ok
Het Splash 2 + Het Splash 1 = ok
Het Splash 2 + Het Splash 1 + Het Frame = ok
Het Splash 2 + Hom Splash 1 = ok
Het Splash 2 + Hom Splash 1 + Het Frame = ok
Het Splash 3 + Het Splash 1 = ok
Het Splash 3 + Het Splash 1 + Het Frame = ok

It's impossible for a horse to be Het Splash 3 and Hom Splash 1 because Splash 1 and Splash 3 are located on the same gene. However, Het Splash 2 and Hom Splash 1 is possible because Splash 2 is located on a different gene than Splash 1/Splash 3.

Really? I thought that Splash(MITF) was the gene and Splash 1 and Splash 3 were 2 different alleles for that gene. According to the genetics guide, Splash(MITF) is the gene and it is located on chromosome 16. I'd assume that chromosome 16 contains a lot of other essential genetic information besides the specific mutation that causes splash. Or is MITF another name for chromosome 16?

MITF (Splash)
Gene Fundamentals
Scientific Designation
Official abbreviated name is MITF
Proper full name is Microphthalmia-associated transcription factor
Located on chromosome 16

And the genetics guide information for Splash 2.

PAX3 (Splash 2)
Gene Fundamentals
Scientific Designation
Official abbreviated name is PAX3
Proper full name is Paired box 3
Located on chromosome 6

The only information on that post about splash and frame just says that adding splash and frame can increase the risk of a dead foal if you are breeding horses that also have KIT mutations. I don't see anything there that says hom splash 2, hom frame, etc. are always lethal even without the presence of any KIT mutations. I think this is why new players don't always know that certain splash and frame crosses are lethal even after they have read the KIT mutation load post. The post only talks about how Splash and Frame increase white factor and can make certain combinations of KIT mutations more likely to be lethal. The KIT mutation chart and calculation matrix are incredibly helpful for when you are planning to combine certain KIT mutations but they say nothing about Splash and Frame crosses.

This is all the information I could find about Splash and Frame in that post.

"I have created a chart to show you how risky different crosses are. Remember adding splash, frame and high white factor parents to the mix greatly increases your risk of a lethal foal."

"The more mutations on a foal the higher it's white factor. Beware of breeding risky crosses when splash and frame are also in the mix. They increase the over all white factor and your risk of a lethal foal."

"No splash and frame increase your white factor. They do not increase the load directly."

I think that adding a link to the KIT Mutation Load post in the Genetics Guide would be extremely helpful for new players and players who don't use the forum, and adding some information about Splash and Frame lethal crosses would be useful too. I think it would also help to decrease the number of forum posts saying things like "Help! Why did my foal die?!" or "My foal died! NOT FAIR!!!". People can't complain that certain gene combinations are lethal if the information is all in the official genetics guide(or linked to in the genetics guide) that they should have read before breeding for fancy colors and patterns. :D Not totally sure why people complain that their game foals died because they combined lethal genes when real life foals sadly die all too often from a wide variety of causes, especially since this game is based on reality, but that's a different topic.