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That's Paints list and I swear I look it up at least twice a week. There is also a table in the documents of the Facebook discussion group, but I find it a little difficult to decipher when I'm stressed!

I got it from one of the other members, and I think Abbey added one to it, and I did also. I also copied and pasted into a word doc, and saved it in My Documents. I check it at least a couple of times a week.

Technically speaking, I believe that "lethal white" is used to refer to the frame gene, which used to be called "Lethal White Overo," which is why, in the game, frame is signified by Olw.
It causes an incomplete digestive tract in the foal so that it dies of impaction colic a couple of days after it is born, not something anyone would want to subject a foal to.

The "White" Kit mutations are correctly called "Dominant White," and they break the Kit gene so seriously that if there is not an unmutated kit gene paired with the mutated one, the foal dies in the uterus before it is born. In the game, White 1 and White 2 represent seriously broken Kit variations and produce more white on the body than White 3 and White 4. This is why Sb1 and 2 can be safely combined with W3 and W4, but not with W1 and W2. The sabino mutations do not break the Kit gene as drastically as the Dominant White mutations. This is why sabinos can be interbred safely.

Roan and tobiano also break the Kit gene, but these mutations do impair the other functions of that gene enough to make them dangerous either when homozygous or when paired with the other Kit mutations.

There used to be a great explanation of the Kit mutations online, which was fairly understandable even to a non-science major, but I think it is no longer available. The one scientific paper I did find tonight was even more technical and left me shaking my head, so I didn't recommend it.

I didn't talk about the splash mutations because I don't know enough about them to give even a general discussion as I did for the dominant whites. What I find intriguing is that although Splash 3 is homozygous lethal, it can safely be combined with Splash 1, even though they are on the same gene.

Hey guys, I am confused.

So I always thought that the way the lethal genes worked is that if you got a certain combo it was game over for the foal. So for example, if you got a foal that was homozygous W1, (so Kitw1Kitw1), it would be born stillborn. So OlwOlw, Kitsb1KitW1, homozygous splash 3, etc. would all guarantee a dead foal. I always though the probabilities given were decided like this:
Cross a het. W1 stud with a het. sabino 1 mare. The possible combinations of kit genes are: kitW1+kit, kitsb1+kit, kit+kit, and kitW1+kitsb1. From that cross, you have a 1/4 chance of getting a foal with both white 1 and sabino 1, and that foal is guaranteed to be stillborn.

Similarly, if you cross a het. W1 stud with a homo. sabino 1 mare, the possible combinations are: kitW1+kitsb1 and kit+kitsb1. In this case, you have a 50% chance of a dead foal.

This is supported by the fact that there are no lined horses on HJ2 that have any of the lethal combinations. (I checked a few on HAJ as well, and didn't find any there either.)

So following that logic, what's the deal with HHs like Trick or Treat (kitsb1kitW1) or Freaky Friday (OlwOlw)? I guess the idea is that they have somehow been genetically modified to be able to survive having a lethal gene combination? But even though they are living, if they produce a foal with a lethal combo it will die, correct?

My understanding is lethal combinations are ok as long as they are GMTd in rather than "naturally" occurring. Basically the rank specials are all GMTd, but you could do the same yourself if you wanted.

I have a question about Sab3. Can you breed Sab3 to Sab3 and be ok or is that lethal?