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You should be fine. Your stallion can only pass on one of his kit genes, and the mare has only W20, which is ok with either gene, and both of them have low White factors, so should be ok. If either had a high White factor, I would worry a bit more, but with the low White factors things should be safe.

Personally, I find the complete calculation chart more helpful than the color chart because it gives you some additional information. You can view the full chart if you click on the link to open the full calculation matrix google doc.

http://hj2.huntandjump.com/forum/discussion/13757/new-kit-lethality-and-kit-mutation-load-explained#Item_12

The numbers 1-6 that are listed for each KIT allele represent the 6 possible White Factors for the foal, with 1 being None, 2 is Minimal, 3 is Light, 4 is Medium, 5 is Large, and 6 is Extensive. In order to read the chart, look for where the 2 alleles you are interested in crossing intersect. The intersection will contain 6 boxes, with each box representing a potential white factor for the foal. A green box means that a foal born with that specific white factor and a combination of the 2 KIT mutations you are looking at will be safe. A red box for a certain white factor means that a foal born with the 2 KIT mutations you are looking at and that white factor will die. For example, if you look at where w2 and w10 intersect, you will see that foals born with w2 and w10 that have a white factor of none or minimal will be safe, while the ones that have white factors of light, medium, large, and extensive will all die. You don't need to understand how the number for each specific cell is calculated in order to read the chart, so don't worry if you aren't a numbers person.

If you look at the calculation chart for your specific horses, Sabino and white20 are always safe together, and white20 and white2 are only lethal together if the foal has an Extensive white factor. The fact that your foal could potentially have Splash and Frame does complicate things a bit. This is because although Splash and Frame aren't automatically lethal when combined with w20 and w2, they do increase a horse's white factor. If your foal inherits Splash, Frame, or both, it will have a higher white factor which makes it more likely that your foal could end up with an Extensive white factor. This could give you a dead foal if it has w20, w2, and an extensive white factor. If your foal doesn't have both w20 and w2, it will be safe no matter how large its white factor is. Personally, I would probably go ahead and cross these two horses since the chance of your foal being born with a combination of w20, w2, and an Extensive white factor probably isn't very high.

Interesting! That helps clarify how the Splash/Frame interact with Kit. The link you posted went back to the old red/green/yellow chart, but I was able to track down the new chart with the different white factors. For others looking at this thread, it's here: http://hj2.huntandjump.com/forum/discussion/13709/lethal-kit-combinations-have-been-drasticly-updated#Item_3.

I understand from the FAQ/gene guide that, in the game, white factor is a simplified version of multiple factors. By the sounds of it, the amount of white factor isn't necessarily inherited like other genes are. Is that correct? You can't assume that two horses with a white factor of none will produce a foal with white factor of none?

I totally missed that link! Thank you!